WebL-Buthionine sulfoximine ≥97% (by TLC) Supplier: Enzo Life Sciences. Synonyms: L-Buthionine- (S,R)-sulphoximine , L-Buthionine- (S,R)-sulfoximine. L-Buthionine-sulfoximine (BSO) induces oxidative stress in cells by irreversibly inhibiting γ-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione. WebButhionine sulfoximine and a-methyl buthionine sulf- oximine may be useful agents for inhibition of gluta- thione synthesis in various experimental systems. Previous studies in this laboratory showed that prothionine sulfoximine (S-n-propyl homocysteine sulfoximine) is a very effective inhibitor of y-glutamylcysteine synthetase, and that ...
L -Buthionine-sulfoximine = 97 TLC 83730-53-4 - Sigma-Aldrich
WebDL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2 ... WebJan 11, 2024 · 丁硫氨酸-亚砜亚胺用途. L-Buthionine- (S,R)-sulfoximine 是一种具有细 … getting spots out of clothes
L-Buthionine-(S,R)-sulfoximine STEMCELL Technologies
WebL-buthionine-S,R-sulfoximine (BSO) selectivley inhibits glutathione (GSH) synthesis. Malignant melanoma may be uniquely dependent on GSH and its linked enzymes, glutathione S-transferase (GST) and GSH-peroxidase, for metabolism of reactive orthoquinones and peroxides produced during melanin synthesis. We compared the in … WebNov 6, 2015 · Buthionine sulfoximine (BSO) is a specific inhibitor of γ-glutamyl-cysteine synthetase and is thus able to block the rate-limiting step of GSH biosynthesis. Depletion of GSH by BSO restores the sensitivity of resistant tumors to drugs in vitro and in vivo . A number of research groups undertook phase I clinical studies to determine clinically ... christopher house rehab denver