WebFeb 2, 2024 · Notably, Cgas or Sting deficiency reduced the production of IFNβ drastically in mice infected with S. japonicum. Intriguingly, intravenous administration of recombinant IFNβ exacerbated liver damage and promoted egg … Six-millimetre skin biopsies from healthy individuals or patients with COVID-19 were cut into three equal pieces and one piece was snap-frozen to measure the baseline gene expression. The two remaining pieces were cultured in 200 μl of DMEM 10% FBS, 1% penicillin–streptomycin in the presence or not of 0.5 μg … See more Studies were approved by the institutional review and privacy boards of the Lausanne University Hospital CHUV, and the local ethics committee, in accordance with the Helsinki Declaration: CER-VD 2024-02204 for … See more Lung and brain of the mice were homogenized in Vero-E6 cell-culture medium (DMEM + 10% FBS + P/S). Homogenized mix … See more For scoring the endotheliopathy in skin samples, the outer and inner diameters of the post-capillary vessels of the superficial and middle dermis … See more Twelve-to-sixteen-week-old female K18-hACE C57BL/6J transgenic mice (strain: 2B6.Cg-Tg(K18-ACE2)2Prlmn/J) were obtained from The Jackson Laboratory. Mice were housed in … See more
STING-dependent sensing of self-DNA drives silica-induced lung ... - Nature
WebAlthough cGAS-STING signaling pathway shows critical function in the maintenance of gut homeostasis, overactive cGAS-STING signaling pathway leads to gastrointestinal (GI) … WebFeb 9, 2024 · The cGas-Sting Pathway A DNA sensor known as cGAS was recently shown to be critical in type-I IFN induction ( Sun et al., 2013 ). cGAS detects circulating double-stranded DNA (dsDNA) in the cytosol … show and hide in word
cGAS exacerbates Schistosoma japonicum infection in …
WebHere we show that the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, which controls immunity to cytosolic DNA, is a critical driver of … WebThe cGAS/STING pathway is a cytoplasmic DNA sensor, and activation of the cGAS/STING pathway leads to two independent downstream pathways: type I IFNs through IRF3 and proinflammatory responses through NFκB16. Both the IRF3- and NF-κB-dependent pathways lead to the production of inflammatory growth factors and cytokines, leading to … show and hide polygons in maya hotkeys script