WebJan 13, 2024 · Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (cGAS), along with the adaptor stimulator of interferon genes (STING), are crucial components of the innate immune system, and their study has become a research hotspot in recent years. Many biochemical and structural studies that have … WebJun 12, 2024 · The stimulator of interferon (IFN) genes (STING) pathway constitutes a highly important part of immune responses against various cancers and infections. …
(PDF) An alternatively spliced STING isoform localizes in the ...
WebIn cancer cells, endogenous or therapy-induced DNA damage leads to the abnormal presence of DNA in the cytoplasm, which triggers the activation of cGAS (cyclic GMP-AMP synthase) and STING (stimulator of interferon genes). STAT2 suppresses the cGAMP-induced expression of IRF3-dependent genes by bindi … WebDescription: STING agonist Synonym: Cyclic [G (2’,5’)pA (3’,5’)p], cyclic GMP-AMP; c-GpAp sodium salt CAS number: 1441190-66-4 Formula: C 20 H 22 N 10 O 13 P 2 •2Na Molecular weight: 718.38 Purity: ≥ 95% by LC/MS Solubility: 50 mg/ml in water Quality control: The biological activity has been confirmed using cellular assays. sccd log in
Advances in cGAS-STING Signaling Pathway and Diseases
WebcGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), … WebMar 31, 2016 · View Full Report Card. Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn … WebJun 22, 2024 · Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is an important novel role in the immune system. Multiple STING agonists were developed for cancer therapy study with great results achieved in pre-clinical work. Recent progress in the mechanical understanding of … scce abbreviation physical therapy