WebThe purpose of this study was to identify and characterize new crystalline bulking agents applicable to freeze-dried pharmaceuticals. Thermal analysis of heat-melt sugar and sugar alcohol solids as well as their frozen aqueous solutions showed high crystallization propensity of meso-erythritol and D-mannitol. WebNov 1, 2024 · Bulking agent Crystallization Sucrose Protein stability Glass transition Collapse Abbreviations AA amino acid AU absorbance unit aFD after freeze-drying API …
Cellulose microcrystalline, powder, 20um 9004-34-6 - Sigma-Aldrich
WebBulking agent, opacifier, anti-caking agent, extrusion aid and stabilizer for foams and emulsions. High purity cellulose powders for partition chromatography. Packaging 50, 500 g in poly bottle 1 kg in poly bottle Features and Benefits Amorphous regions are hydrolyzed leaving crystalline microfibrils. Forms thixotropic gels, good thermal stability. WebApr 1, 2011 · Freezing the typical protein formulation results in two phases: about 80% of the frozen solution consists of crystals of pure ice and the remaining 20% is an amorphous or partially crystalline phase that contains all the excipients and protein (concentrated about 5X) along with some amorphous water left behind after the ice crystals have formed … bodice sloper pattern
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WebOct 23, 2024 · Other uses are as a bulking agent in tablet sugar-coating processes and as an extender and opacifier in tablet film-coatings. ... It occurs as a white, crystalline powder with a saline taste. Sodium chloride is used widely in parenteral products to produce isotonic solutions. In oral products, it functions as a diluent (capsules and direct ... WebMar 1, 2008 · Mannitol is popular as a crystalline bulking agent in freeze-drying, but tends to form different crystalline modifications which may negatively impact storage stability. … WebMar 23, 2024 · In such situations, it is a common practice to add a crystalline bulking agent such as mannitol or glycine to the formulation. The high crystallization propensity of these agents coupled with their high eutectic temperature enables primary drying at high temperatures thereby reducing the overall cycle time. bodice traduction