Web16 nov. 2024 · Statins are HMG-CoA reductase inhibitors, drugs that have been around since 1987. Lovastatin was the first approved statin; a naturally occurring statin found in … WebFibrates stimulate PPARɑ receptors [6] FDA-APPROVED INDICATIONS Fenofibrate (Antara®, Fenoglide®, Lipofen®, Lofibra®, Tricor®, Triglide®) Dyslipidemia - to decrease total cholesterol, LDL, triglycerides, and apolipoprotein B, and to increase HDL Severe hypertriglyceridemia (≥ 1000 mg/dl)

Fibrate - Wikipedia

WebFibrates activate specific transcription factors belonging to the nuclear hormone receptor superfamily, termed peroxisome proliferator … WebFibrates: Coadministration of NEXLIZET with fibrates other than fenofibrate is not recommended. Fenofibrate and ezetimibe may increase cholesterol excretion into the … outwell give

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Web- Fibrates MOA: changes production levels lipoproteins but different pathway than statins (liver is still site of action) Adverse effects: Heartburn, abdominal pain, diarrhea, nausea, flatulence, skin reactions (itchiness, redness, rash), rhabdomyolysis, liver damage - Niacin MOA: Exact mechanism is unknown, but reduces synthesis of LDL, CLDL, and increases … WebHeadache (most common), nausea and vomiting, vertigo, confusion. Severe: pink skin and mucosa, hyperpyrexia, extrapyramidal features, arrythmias. Normal - <3%; smoker 3-10%; posioning 10-30%; severe toxicity >30%. Indications for hyperbaric O2 - loss of conscioussness, neuro signs other than headache, myocardial ischaemia, pregnancy. Webmost effective drug for lowering LDL. Toxicity. hepatotoxicity. myopathy. especially when used in combination with fibrates and niacin. inhibitors of P450 can ↑ serum … outwell glendo