2024 Phgdh cancer

Phgdh cancer

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August undefined, 2024

WebJan 14, 2024 · Our results indicate that inhibition of PHGDH will augment the therapeutic efficacy of a serine depleted diet. Cancer cells adapt their metabolism to support growth and survival, leading to... WebNational Center for Biotechnology Information

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WebPHGDH. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … WebFeb 20, 2024 · PHGDH (Phosphoglycerate Dehydrogenase) is the first branch enzyme in the serine biosynthetic pathway and plays a vital role in several cancers. However, little is known about the clinical significance of PHGDH in endometrial cancer. Clinicopathological data of endometrial cancer were downloaded from the Cancer Genome Atlas database (TCGA). troy splash

PHGDH heterogeneity potentiates cancer cell dissemination

WebImportantly, we find that PHGDHhigh breast cancer cell lines are exquisitely sensitive to inhibition of the NAD+ salvage pathway. Further, we find that PHGDH protein levels and those of the rate-limiting… Show more NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway. WebDec 30, 2024 · The levels of Josephin-2 and phosphoglycerate dehydrogenase (PHGDH) were determined using RT-qPCR and western blotting. Cell proliferation, migration and invasion were assessed by CCK-8, colony formation and Transwell. Spheroid-forming assay was performed to assess the cancer stem cell (CSC)-phenotype of HCC cells. WebAug 23, 2024 · Phosphoglycerate dehydrogenase (PHGDH) is an essential enzyme catalyzing the synthesis of amino acid serine. PHGDH is important for maintaining the poorly differentiated, stem-like state of cancer stem-like cells (CSLCs). Typically, high levels of PHGDH associate with enhanced proliferation and poor prognosis in various types of … troy ssa

Increased Expression of PHGDH and Prognostic ... - ScienceDirect

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WebMay 5, 2024 · The abnormal expression and genetic deficiency of PHGDH have been observed in various diseases. Herein, we comprehensively summarize the pathological role of PHGDH in some closely related tumor diseases, including hepatocellular carcinoma, breast cancer, melanoma, lung cancer, glioma, colon carcinoma, leukemia, multiple … WebSep 1, 2024 · Brain-metastatic cancer cells had increased expression of PHGDH, an enzyme in the serine-synthesis pathway. PHGDH expression was required for proliferation in low-serine conditions in vitro and brain metastasis in vivo. Pharmacologic PHGDH inhibition suppressed brain metastasis, so PHGDH inhibitors may be worth investigating. troy ssqd swivelWebOct 18, 2024 · Accordingly, PHGDH inhibitor treatment no longer impaired tumour growth when c-Jun activity was reduced. Moreover, they demonstrate the relevance of their … troy stafford

"WebJan 3, 2024 · Being the rate-limiting enzyme within the serine biosynthesis pathway, phosphoglycerate dehydrogenase (PHGDH) is abnormally overexpressed in numerous malignant tumor cells and is a promising target for cancer treatment. Here, we report a series of novel PHGDH inhibitors using a focused compound screening and structural … " - Phgdh cancer

Phgdh cancer

Renal UTX-PHGDH-serine axis regulates metabolic disorders in …

WebNCT-503 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=2.5 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.NCT-503 exhibits EC50 of 8-16 uM for the PHGDH-dependent cell lines; has reasonable aqueous solubility and favorable ADME …

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WebMay 18, 2024 · Phosphoglycerate dehydrogenase (PHGDH) catalyzes the first step in the synthesis of the amino acid serine, important for protein synthesis, one-carbon metabolism, lipid production, redox homeostasis, and other key processes of normal and cancer metabolism. While PHGDH is often overexpressed in cancer cells, how it is regulated has … WebJun 1, 2016 · PHGDH was identified as a predictor for unfavorable prognosis in breast cancer but not in lung cancer, suggesting potential tissue-specific roles for PHGDH.

WebThe gene encoding the enzyme 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the first committed step of serine biosynthesis, is overexpressed in tumors and cancer cell lines via focal amplification and nuclear factor erythroid-2-related factor 2 (NRF2)-mediated up-regulation. WebApr 28, 2024 · PHGDH: Non-small cell lung cancer: PHGDH is highly expressed in a subset of patients with poor prognosis: 2024 : PHGDH: Pancreatic cancer: Increased PHGDH expression correlates with tumor size, lymph node metastasis, and cancer stage: 2024 : PHGDH, PSAT1, PSPH: Glioblastoma

WebMay 9, 2024 · Member the National Cancer Institute for the IMAT and Tumor Biology Study Sections, ... PKCζ represses the expression of two key … WebJul 4, 2024 · Together, our results reveal a metabolic homeostasis regulation mediated by a renal UTX-PHGDH-serine axis. Subject terms: Nephrology, Physiology. ... Hubei Cancer Hospital and Union Hospital of Tongji Medical College (approval numbers (2024)16, LLHBCH2024YN-015, and (2024)S196, respectively), all subjects included in the study …

WebNov 14, 2016 · Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway. In breast cancer and several other types of cancer, increased PHGDH expression is associated with patient mortality.

WebApr 28, 2024 · A model in which PHGDH activity modulates redox homeostasis may reconcile prior studies investigating PHGDH's role in supporting serine-dependent cell anabolism. A major unsolved question in the field is understanding whether cancer cells utilize extracellular serine differently from serine synthesized de novo. troy ssi officeWebFeb 5, 2024 · PHGDH expression is increased in pancreatic cancer and it is associated with tumor size, lymph node metastasis, and TNM state of pancreatic cancer patients. To … troy stafford azWebFigure 1 PHGDH is increased in platin-resistant ovarian cancer and predicts poor prognosis of patients with ovarian cancer.(A) PHGDH expression was assessed using Western blot in platin-sensitive (parental) and their platin-resistant (DDP) SKOV3 and A2780 cells. The relative expression was noted under the blots. (B) PHGDH expression was investigated in … troy stafford attorneyWebMar 31, 2024 · Triple-negative breast cancer (TNBC) is a heterogeneous group of breast cancers, characterized by lack of expression of estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 gene amplification, making it unresponsive to endocrine therapy and HER2-targeted treatment. troy sssWebMar 29, 2024 · PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer. PHGDH expression increases with progression … troy standard lightingWebJun 15, 2024 · d -3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target. However, whether PHGDH is critical for the proliferation or homeostasis of tissues following the postnatal period is unknown. Methods troy stahl ely mnWebIdentifying increased PHGDH expression as a resistance mechanism for a variety of cancer therapeutics offers the opportunity to combine PHGDH inhibition with small molecule … troy st football score