Webb1 nov. 2024 · MG53 has been proven to be involved in repairing cell membrane damage. It has a protective effect on I/R injury in multiple oxygen-dependent organs, such as the … Webb27 aug. 2024 · Background . The heart is one of the most commonly affected organs during sepsis. Mitsugumin-53 (MG53) has attracted attention in research due to its cardioprotective function. However, the role of MG53 in sepsis-induced myocardial dysfunction (SIMD) remains unknown. The purpose of this study was to explore the …
MG53: Biological Function and Potential as a Therapeutic Target
Webb26 feb. 2024 · Mechanistically, in addition to MG53-induced dysregulation of IR and IRS-1, it also blocks insulin signaling by upregulating peroxisome proliferator-activated receptor … Webb11 okt. 2024 · MG53 is a protein that regulates the cell membrane repair process, and it’s been suggested that it might play a role in diabetes. Here, the authors demonstrate that circulating MG53 functions as ... helma musterhaus kaarst
Protective role of MG53 against ischemia/reperfusion injury on multipl…
Webb21 nov. 2024 · The role of MG53 in repairing cell membrane damage The importance of the cell membrane to the organism is self-evident. It is a barrier to prevent extracellular substances from freely entering the cell, to ensure the relative stability of the intracellular environment, and to make various biochemical reactions proceed in an orderly manner ( … Webb28 nov. 2024 · For instance, short-term intensive exercise increases serum MG53 levels in the mdx dystrophic mice (but not in the wt mice) as a result of muscle injury and subsequent leakage of MG53. 21 Nevertheless, understanding the potential role of MG53 in physiological regulation of insulin sensitivity by physical activity and nutrients requires … Webb7 maj 2015 · Researchers have previously analyzed MG53’s role in the development of metabolic disorders[15,16]. In particular, Song et al. indicted MG53 as a perpetrator of metabolic syndrome, citing its participation in downregulating insulin receptor substrate-1 (IRS-1) as a problematic source of insulin resistance . helma musterhaus lehrte